Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.57 |
| ▸ | TUBB1 | Q9H4B7 | 10/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.50 |
| ▸ | TUBB | P07437 | 5/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177135 | 1.00 | ABCG2 (0.57) | ABCG2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL16994700 | 0.81 | TUBB1 (0.65) | ABCG2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL9644217 | 0.76 | ABCG2 (0.79) | ABCG2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL13220873 | 0.74 | ALDH1A1 (0.73) | ABCG2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL177152 | 0.74 | ABCG2 (0.55) | ABCG2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL177153 | 0.74 | ABCG2 (0.55) | ABCG2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL374153 | 0.73 | ABCG2 (0.62) | ABCG2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL11265553 | 0.73 | ABCB1 (0.70) | ABCG2ABCB1ALDH1A1POLB | |
| SCHEMBL7532294 | 0.72 | ALDH1A1 (0.53) | ABCG2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL7532295 | 0.72 | ALDH1A1 (0.53) | ABCG2TUBB1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9707205-B2 | S1P receptors modulators and their use thereof | AKAAL PHARMA PTY LTD. (AU) | 2017-07-18 | — | — | US | disclosed |
| EP-2344484-B1 | S1P RECEPTORS MODULATORS AND USE THEREOF | AKAAL PHARMA PTY LTD (AU) | 2016-06-08 | — | — | EP | disclosed |
| US-20160038455-A1 | S1P RECEPTORS MODULATORS AND THEIR USE THEREOF | AKAAL PHARMA PTY LTD. (AU) | 2016-02-11 | — | — | US | disclosed |
| US-9193716-B2 | S1P receptors modulators and their use thereof | AKAAL PHARMA PTY LTD. (AU) | 2015-11-24 | — | — | US | disclosed |
| US-20140066427-A1 | S1P Receptors Modulators and Their Use Thereof | AKAAL PHARMA PTY LTD. (AU) | 2014-03-06 | — | — | US | disclosed |
| US-8592399-B2 | S1P receptors modulators and their use thereof | AKAAL PHARMA PTY LTD. (AU) | 2013-11-26 | — | — | US | disclosed |
| US-20110318388-A1 | S1P Receptors Modulators and Their Use Thereof | AKAAL PHARMA PTY LTD (AU) | 2011-12-29 | — | — | US | disclosed |
| EP-2344484-A1 | S1P RECEPTORS MODULATORS AND THEIR USE THEREOF | Akaal Pharma Pty Ltd (AU) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010043000-A1 | S1P RECEPTORS MODULATORS AND THEIR USE THEREOF | AKAAL PHARMA PTY LTD (AU) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160038455-A1 | S1P RECEPTORS MODULATORS AND THEIR USE THEREOF | S1PR1, S1PR5, S1PR2 | ABCG2 3806/4885TUBB1 4207/4885TUBB4A 4451/4885 |
| US-20110318388-A1 | S1P Receptors Modulators and Their Use Thereof | S1PR1, S1PR5, S1PR2 | ABCG2 3806/4885TUBB1 4207/4885TUBB4A 4451/4885 |
| US-20140066427-A1 | S1P Receptors Modulators and Their Use Thereof | S1PR1, S1PR2, S1PR5 | ABCG2 4586/4885TUBB1 4322/4885TUBB4A 4623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.