Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 12/20 | 0.72 |
| ▸ | BLK | P51451 | 3/20 | 0.50 |
| ▸ | LYN | P07948 | 2/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17962785 | 0.84 | FYN (0.49) | FYNBLKPIK3CGPIK3CDRET | |
| SCHEMBL17725997 | 0.84 | FYN (1.00) | FYNBLKLYNPIK3CGPIK3CD | |
| SCHEMBL20533626 | 0.81 | ADORA2A (0.49) | FYNBLKPIK3CGPIK3CDRET | |
| SCHEMBL17726000 | 0.80 | FYN (1.00) | FYNBLKLYNPIK3CGPIK3CD | |
| SCHEMBL19500708 | 0.79 | SRC (0.56) | FYNBLKLYNPIK3CGPIK3CD | |
| SCHEMBL19500707 | 0.79 | SRC (0.56) | FYNBLKLYNPIK3CGPIK3CD | |
| SCHEMBL17725994 | 0.79 | FYN (0.85) | FYNBLKLYNPIK3CGPIK3CD | |
| SCHEMBL17726068 | 0.79 | FYN (1.00) | FYNBLKLYNPIK3CGPIK3CD | |
| SCHEMBL18250072 | 0.77 | PIK3CG (0.53) | FYNBLKPIK3CGPIK3CDRET | |
| SCHEMBL17726005 | 0.77 | FYN (0.81) | FYNBLKLYNPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186796-A1 | COMPOUNDS AND USES THEREOF | LEAD DISCOVERY SIENA S.R.L. (IT) | 2018-07-05 | — | — | US | disclosed |
| US-20180186796-A1 | COMPOUNDS AND USES THEREOF | LEAD DISCOVERY SIENA S.R.L. (IT) | 2018-07-05 | — | — | US | disclosed |
| EP-3212649-A2 | COMPOUNDS AND USES THEREOF | Lead Discovery Siena S.r.l. (IT) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016066755-A2 | COMPOUNDS AND USES THEREOF | LEAD DISCOVERY SIENA S.R.L. (IT) | 2016-05-06 | — | — | WO | disclosed |
| WO-2016066755-A2 | COMPOUNDS AND USES THEREOF | LEAD DISCOVERY SIENA S.R.L. (IT) | 2016-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186796-A1 | COMPOUNDS AND USES THEREOF | FYN, SRC, HCK | FYN 1/4885BLK 64/4885LYN 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.