Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | HCK | P08631 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.56 |
| ▸ | MTOR | P42345 | 2/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.56 |
| ▸ | PRKDC | P78527 | 2/20 | 0.56 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.56 |
| ▸ | ADK | P55263 | 7/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.46 |
| ▸ | CLK2 | P49760 | 3/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19500707 | 1.00 | SRC (0.56) | SRCKDRPIK3CGPIK3CDABL1 | |
| SCHEMBL20533626 | 0.86 | ADORA2A (0.49) | SRCKDRPIK3CGPIK3CDABL1 | |
| SCHEMBL17962785 | 0.86 | FYN (0.49) | SRCKDRPIK3CGPIK3CDABL1 | |
| SCHEMBL18250072 | 0.80 | PIK3CG (0.53) | SRCKDRPIK3CGPIK3CDABL1 | |
| SCHEMBL17714345 | 0.79 | FYN (0.72) | SRCKDRPIK3CGPIK3CDABL1 | |
| SCHEMBL868521 | 0.79 | DYRK3 (0.51) | SRCKDRPIK3CGPIK3CDABL1 | |
| SCHEMBL868744 | 0.78 | PIK3CD (0.51) | SRCKDRPIK3CGPIK3CDABL1 | |
| SCHEMBL18250077 | 0.77 | MTOR (0.54) | SRCKDRPIK3CGPIK3CDABL1 | |
| SCHEMBL30877161 | 0.77 | MTOR (0.54) | SRCKDRPIK3CGPIK3CDABL1 | |
| SCHEMBL17962836 | 0.76 | PRKD3 (0.54) | SRCKDRPIK3CGPIK3CDADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266537-B2 | 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof | St. Chuan University (CN) | 2019-04-23 | — | — | US | disclosed |
| US-20170305920-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | SI CHUAN UNIVERSITY (CN) | 2017-10-26 | — | — | US | disclosed |
| US-20170305920-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | SI CHUAN UNIVERSITY (CN) | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305920-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | DPYD, TYMP, WEE1 | SRC 1111/4885KDR 2340/4885PIK3CG 1066/4885 |
| US-10266537-B2 | 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof | DPYD, TYMP, WEE1 | SRC 1111/4885KDR 2340/4885PIK3CG 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.