Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 9/20 | 0.73 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17714315 | 1.00 | PTGES (0.73) | PTGESPDE10AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL19542568 | 0.88 | PTGES (0.69) | PTGESPDE10AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL17723498 | 0.88 | PTGES (0.72) | PTGESPDE10AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL17714466 | 0.88 | PTGES (0.67) | PTGESPDE10AGAAHTR3A | |
| SCHEMBL17723452 | 0.85 | PTGES (0.79) | PTGESPDE10AKDM4EALDH1A1GAA | |
| SCHEMBL17714465 | 0.85 | PTGES (0.79) | PTGESPDE10AKDM4EALDH1A1GAA | |
| SCHEMBL17714482 | 0.85 | PTGES (0.79) | PTGESPDE10AKDM4EALDH1A1GAA | |
| SCHEMBL17714467 | 0.85 | PTGES (0.54) | PTGESKDM4EALDH1A1GAAUSP2 | |
| SCHEMBL17723493 | 0.84 | PTGES (1.00) | PTGESPDE10A | |
| SCHEMBL20484799 | 0.84 | PTGES (1.00) | PTGESPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074829-B | For inhibiting microsomal prostaglandin E2Novel methyl-piperidine compounds of synthetase-1 | 伊莱利利公司 | 2020-11-13 | — | — | CN | disclosed |
| EP-3221304-B1 | NOVEL CARBOXYLIC ACID COMPOUNDS USEFUL FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 | LILLY CO ELI (US) | 2019-07-24 | — | — | EP | disclosed |
| US-20180251446-A1 | Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | LILLY CO ELI (US) | 2018-09-06 | — | — | US | disclosed |
| US-20180250282-A1 | Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | LILLY CO ELI (US) | 2018-09-06 | — | — | US | disclosed |
| US-9969714-B2 | Carboxylic acid compounds useful for inhibiting microsomal prostaglandin E2 synthase-1 | ELI LILLY AND COMPANY (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969714-B2 | Carboxylic acid compounds useful for inhibiting microsomal prostaglandin E2 synthase-1 | ELI LILLY AND COMPANY (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969714-B2 | Carboxylic acid compounds useful for inhibiting microsomal prostaglandin E2 synthase-1 | ELI LILLY AND COMPANY (US) | 2018-05-15 | — | — | US | disclosed |
| US-9962375-B2 | Methyl-piperidine compounds useful for inhibiting microsomal prostaglandin E2 synthase-1 | ELI LILLY AND COMPANY (US) | 2018-05-08 | — | — | US | disclosed |
| US-9962375-B2 | Methyl-piperidine compounds useful for inhibiting microsomal prostaglandin E2 synthase-1 | ELI LILLY AND COMPANY (US) | 2018-05-08 | — | — | US | disclosed |
| US-9962375-B2 | Methyl-piperidine compounds useful for inhibiting microsomal prostaglandin E2 synthase-1 | ELI LILLY AND COMPANY (US) | 2018-05-08 | — | — | US | disclosed |
| US-20170326128-A1 | Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | ELI LILLY AND COMPANY | 2017-11-16 | — | — | US | disclosed |
| US-20170326128-A1 | Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | ELI LILLY AND COMPANY | 2017-11-16 | — | — | US | disclosed |
| US-20170326128-A1 | Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | ELI LILLY AND COMPANY | 2017-11-16 | — | — | US | disclosed |
| US-20170313679-A1 | Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | ELI LILLY AND COMPANY | 2017-11-02 | — | — | US | disclosed |
| US-20170313679-A1 | Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | ELI LILLY AND COMPANY | 2017-11-02 | — | — | US | disclosed |
| US-20170313679-A1 | Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | ELI LILLY AND COMPANY | 2017-11-02 | — | — | US | disclosed |
| EP-3230278-A1 | NOVEL METHYL-PIPERIDINE COMPOUNDS USEFUL FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 | Eli Lilly and Company (US) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016069376-A1 | NOVEL METHYL-PIPERIDINE COMPOUNDS USEFUL FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 | ELI LILLY AND COMPANY (US) | 2016-05-06 | — | — | WO | disclosed |
| WO-2016069376-A1 | NOVEL METHYL-PIPERIDINE COMPOUNDS USEFUL FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 | ELI LILLY AND COMPANY (US) | 2016-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170313679-A1 | Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | PTGS1, PTGES, PTGS2 | PTGES 2/4885PDE10A 784/4885KDM4E 2912/4885 |
| US-20170326128-A1 | Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | PTGS1, PTGES, PTGER1 | PTGES 2/4885PDE10A 1605/4885KDM4E 581/4885 |
| US-20180251446-A1 | Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | PTGS1, PTGES, PTGS2 | PTGES 2/4885PDE10A 784/4885KDM4E 2912/4885 |
| US-20180250282-A1 | Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | PTGS1, PTGES, PTGER1 | PTGES 2/4885PDE10A 1915/4885KDM4E 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.