Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.53 |
| ▸ | IDO1 | P14902 | 3/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MPI | P34949 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | METAP1 | P53582 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335177 | 0.80 | HSP90AA1 (0.57) | HSP90AA1IDO1HSP90AB1PSMB5CYP2C19 | |
| SCHEMBL11277500 | 0.77 | CYP2C19 (0.60) | HSP90AA1IDO1HSP90AB1PSMB5CYP2C19 | |
| SCHEMBL1773408 | 0.77 | IDO1 (0.48) | IDO1MAPTTDP1APP | |
| SCHEMBL24716144 | 0.76 | KDM4E (0.61) | HSP90AA1IDO1HSP90AB1PSMB5CYP2C19 | |
| SCHEMBL13797358 | 0.76 | CYP2C19 (0.62) | HSP90AA1IDO1HSP90AB1PSMB5CYP2C19 | |
| SCHEMBL28124508 | 0.75 | CYP2C19 (0.66) | HSP90AA1IDO1HSP90AB1PSMB5CYP2C19 | |
| SCHEMBL28124509 | 0.75 | CYP2C19 (0.66) | HSP90AA1IDO1HSP90AB1PSMB5CYP2C19 | |
| SCHEMBL7258719 | 0.72 | KDM4E (0.70) | HSP90AA1IDO1HSP90AB1PSMB5KDM4E | |
| SCHEMBL1920452 | 0.72 | KDM4E (0.70) | HSP90AA1IDO1HSP90AB1PSMB5KDM4E | |
| SCHEMBL28677018 | 0.71 | KDM4E (0.68) | HSP90AA1IDO1HSP90AB1PSMB5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112282-A1 | IDO INHIBITORS AND THERAPEUTIC USES THEREOF | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. | 2011-05-12 | — | — | US | disclosed |
| WO-2009127669-A2 | IDO INHIBITORS AND THERAPEUTIC USES THEREOF | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (US) | 2009-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112282-A1 | IDO INHIBITORS AND THERAPEUTIC USES THEREOF | IDO1, IDO2, IDH3B | HSP90AA1 2590/4885IDO1 1/4885HSP90AB1 1611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.