Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.52 |
| ▸ | BTK | Q06187 | 17/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.51 |
| ▸ | LCK | P06239 | 5/20 | 0.51 |
| ▸ | JAK3 | P52333 | 5/20 | 0.51 |
| ▸ | ITK | Q08881 | 5/20 | 0.51 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.50 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | YES1 | P07947 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | FGR | P09769 | 1/20 | 0.47 |
| ▸ | FER | P16591 | 1/20 | 0.47 |
| ▸ | CSK | P41240 | 1/20 | 0.47 |
| ▸ | TEC | P42680 | 1/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.47 |
| ▸ | BMX | P51813 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410076 | 0.81 | BTK (0.72) | SRCBTKEGFRLCKJAK3 | |
| SCHEMBL19176242 | 0.79 | NUDT14 (0.58) | SRCBTKEGFRLCKNUDT14 | |
| SCHEMBL27586498 | 0.77 | NUDT14 (0.58) | SRCBTKEGFRLCKJAK3 | |
| SCHEMBL25069027 | 0.74 | SRC (0.76) | SRCEGFRLCKNUDT14NUDT5 | |
| SCHEMBL22364026 | 0.74 | FYN (0.55) | SRCEGFRABL1FYNHCK | |
| SCHEMBL2601379 | 0.73 | BTK (0.63) | SRCBTKEGFRLCKJAK3 | |
| SCHEMBL19335171 | 0.73 | FYN (0.52) | SRCEGFRABL1FYNHCK | |
| SCHEMBL2562149 | 0.72 | BTK (0.80) | SRCBTKEGFRLCKJAK3 | |
| SCHEMBL2562146 | 0.72 | BTK (0.80) | SRCBTKEGFRLCKJAK3 | |
| SCHEMBL15163859 | 0.72 | BTK (0.80) | SRCBTKEGFRLCKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081435-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-05-04 | — | — | EP | disclosed |