Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | CALCRL | Q16602 | 4/20 | 0.39 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | PER2 | O15055 | 1/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3694085 | 0.89 | SIGMAR1 (0.38) | SIGMAR1CALCRLRAMP1HDAC4HDAC3 | |
| SCHEMBL3703415 | 0.89 | MDM2 (0.39) | — | |
| SCHEMBL17728829 | 0.88 | RAMP1 (0.41) | SIGMAR1CALCRLRAMP1HDAC4HDAC3 | |
| SCHEMBL3700283 | 0.88 | RAMP1 (0.41) | SIGMAR1CALCRLRAMP1HDAC4HDAC3 | |
| SCHEMBL3703209 | 0.85 | SIGMAR1 (0.40) | SIGMAR1CALCRLHDAC4HRH3KDM1A | |
| SCHEMBL16652794 | 0.85 | SIGMAR1 (0.40) | SIGMAR1CALCRLRAMP1HDAC4HDAC3 | |
| SCHEMBL3692682 | 0.84 | SIGMAR1 (0.41) | SIGMAR1HDAC4HRH3KDM1AGPR88 | |
| SCHEMBL3699201 | 0.83 | RAMP1 (0.40) | CALCRLRAMP1 | |
| SCHEMBL17728821 | 0.83 | RAMP1 (0.40) | CALCRLRAMP1 | |
| SCHEMBL3698338 | 0.83 | RAMP1 (0.40) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9850246-B2 | Process for making CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20160130273-A1 | Process for Making CGRP Receptor Antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130273-A1 | Process for Making CGRP Receptor Antagonists | CALCR, CALCRL, VIPR1 | SIGMAR1 654/4885CALCRL 2/4885RAMP1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.