Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.39 |
| ▸ | TP53 | P04637 | 16/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17728827 | 0.89 | SIGMAR1 (0.40) | — | |
| SCHEMBL17728829 | 0.80 | RAMP1 (0.41) | — | |
| SCHEMBL3698148 | 0.80 | RAMP1 (0.45) | MDM2TP53 | |
| SCHEMBL15227809 | 0.80 | RAMP1 (0.45) | MDM2TP53 | |
| SCHEMBL3699201 | 0.80 | RAMP1 (0.40) | — | |
| SCHEMBL3700283 | 0.80 | RAMP1 (0.41) | — | |
| SCHEMBL17728821 | 0.80 | RAMP1 (0.40) | — | |
| SCHEMBL3698338 | 0.80 | RAMP1 (0.40) | — | |
| SCHEMBL26619367 | 0.80 | RAMP1 (0.45) | MDM2TP53 | |
| SCHEMBL3694085 | 0.79 | SIGMAR1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846799-B1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2017-11-15 | — | — | EP | disclosed |
| US-9409916-B2 | Piperidinone carboxamide spirohydantoin CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-08-09 | — | — | US | disclosed |
| US-9296750-B2 | Spirolactam CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-03-29 | — | — | US | disclosed |
| US-9227972-B2 | Aliphatic spirolactam CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-01-05 | — | — | US | disclosed |
| US-20150203496-A1 | ALIPHATIC SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-07-23 | — | — | US | disclosed |
| US-20150111914-A1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-04-23 | — | — | US | disclosed |
| US-20150087641-A1 | HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2015-03-26 | — | — | US | disclosed |
| US-20150005330-A1 | PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-01-01 | — | — | US | disclosed |
| US-8912210-B2 | Piperidinone carboxamide azaindane CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-12-16 | — | — | US | disclosed |
| US-8883807-B2 | Piperidinone carboxamide indane CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-11-11 | — | — | US | disclosed |
| US-20140011827-A1 | PIPERIDINONE CARBOXAMIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2014-01-09 | — | — | US | disclosed |
| US-20130231358-A1 | PIPERIDINONE CARBOXAMIDE INDANE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2013-09-05 | — | — | US | disclosed |
| US-8481556-B2 | Piperidinone carboxamide azaindane CGRP receptor antagonists | Merck, Sharp & Dohms, Corp. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20120122900-A1 | PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231358-A1 | PIPERIDINONE CARBOXAMIDE INDANE CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, CNR2 | MDM2 4811/4885TP53 4872/4885 |
| US-20120122900-A1 | PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, CNR2 | MDM2 4841/4885TP53 4875/4885 |
| US-20150005330-A1 | PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, CNR2 | MDM2 4841/4885TP53 4875/4885 |
| US-20150203496-A1 | ALIPHATIC SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, OPRL1 | MDM2 4447/4885TP53 4783/4885 |
| US-20150111914-A1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, TACR1 | MDM2 4727/4885TP53 4756/4885 |
| US-20150087641-A1 | HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | CCKBR, CALCRL, BDKRB2 | MDM2 4780/4885TP53 4847/4885 |
| US-20140011827-A1 | PIPERIDINONE CARBOXAMIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, CNR2 | MDM2 4821/4885TP53 4874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.