Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GMNN | O75496 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | SLC25A20 | O43772 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CPT2 | P23786 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17241611 | 1.00 | MAPK1 (0.48) | MAPK1MAPTGMNNLMNANPSR1 | |
| SCHEMBL626223 | 0.98 | MAPK1 (0.47) | MAPK1MAPTGMNNLMNANPSR1 | |
| SCHEMBL725613 | 0.98 | MAPK1 (0.47) | MAPK1MAPTGMNNLMNANPSR1 | |
| SCHEMBL625634 | 0.98 | MAPK1 (0.47) | MAPK1MAPTGMNNLMNANPSR1 | |
| Hydrochloric Acid SCHEMBL1773161 | 0.92 | SLC6A5 (0.51) | MAPTGMNNLMNANPSR1MEN1 | |
| Hydrochloric Acid SCHEMBL14060920 | 0.92 | SLC6A5 (0.51) | MAPTGMNNLMNANPSR1MEN1 | |
| Hydrochloric Acid SCHEMBL1828097 | 0.92 | SLC6A5 (0.51) | MAPTGMNNLMNANPSR1MEN1 | |
| Hydrochloric Acid SCHEMBL20258167 | 0.92 | SLC6A5 (0.51) | MAPTGMNNLMNANPSR1MEN1 | |
| SCHEMBL533829 | 0.90 | SLC6A5 (0.52) | MAPTGMNNLMNANPSR1MEN1 | |
| SCHEMBL29077348 | 0.90 | SLC6A5 (0.52) | MAPTGMNNLMNANPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110111459-A1 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID DELIVERY | THE GENERAL HOSPITAL CORPORATION (US) | 2011-05-12 | — | — | US | disclosed |
| WO-2009129523-A2 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID DELIVERY | THE GENERAL HOSPITAL CORPORATION (US) | 2009-10-22 | — | — | WO | disclosed |
| EP-0523189-B1 | CATIONIC LIPIDS FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | VICAL INC (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5459127-A | Drug delivery, extracellular treatment | VICAL, INC. (US) | 1995-10-17 | — | — | US | disclosed |
| EP-0656004-A1 | DUAL FUNCTIONAL ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE AGENTS | CYTOMED, INC. (US) | 1995-06-07 | — | — | EP | disclosed |
| US-5264618-A | For transport of biological active agents into cells for viral agents or polynucleotides or immunogenic peptides | VICAL, INC. (US) | 1993-11-23 | — | — | US | disclosed |
| EP-0523189-A1 | CATIONIC LIPIDS FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | VICAL, INC. (US) | 1993-01-20 | — | — | EP | disclosed |
| WO-1991016024-A1 | CATIONIC LIPIDS FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | VICAL, INC. (US) | 1991-10-31 | — | — | WO | disclosed |