Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.63 |
| ▸ | RAB9A | P51151 | 8/20 | 0.63 |
| ▸ | MEN1 | O00255 | 7/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.63 |
| ▸ | PKM | P14618 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.61 |
| ▸ | STAT3 | P40763 | 9/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.57 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.57 |
| ▸ | STAT1 | P42224 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17732532 | 0.80 | TMIGD3 (0.62) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL1804666 | 0.78 | NPC1 (0.76) | NPC1RAB9AMEN1KMT2APKM | |
| Tenonitrozole SCHEMBL150446 | 0.78 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL375488 | 0.77 | STAT3 (0.58) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL11154311 | 0.76 | STAT3 (0.79) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL13694244 | 0.76 | NSUN3 (0.78) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL11149506 | 0.76 | KMT2A (1.00) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL12974212 | 0.76 | NPC1 (0.78) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL29908278 | 0.76 | NPC1 (0.78) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL375564 | 0.75 | NPC1 (0.69) | NPC1RAB9AMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9333193-B2 | Compositions and methods for treating tuberculosis | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2016-05-10 | — | — | US | disclosed |