Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.36 |
| ▸ | DRD4 | P21917 | 5/20 | 0.36 |
| ▸ | DRD3 | P35462 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | IL2 | P60568 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19703693 | 0.89 | ALDH1A1 (0.39) | HRH4HRH3MGLLDRD2DRD4 | |
| SCHEMBL19703576 | 0.87 | TTR (0.36) | HRH4HRH3MGLLDRD2DRD4 | |
| SCHEMBL19703695 | 0.86 | TTR (0.35) | HRH4HRH3CHIT1MGLLDRD2 | |
| SCHEMBL19703717 | 0.85 | TTR (0.36) | HRH4HRH3DRD2DRD4DRD3 | |
| SCHEMBL17739915 | 0.85 | TTR (0.36) | HRH4HRH3DRD2DRD4DRD3 | |
| SCHEMBL17739959 | 0.85 | TTR (0.36) | HRH4HRH3DRD2DRD4DRD3 | |
| SCHEMBL19703595 | 0.84 | TTR (0.34) | MGLLDRD2DRD4DRD3TTR | |
| SCHEMBL17740210 | 0.84 | TTR (0.36) | HRH4HRH3DRD2DRD4DRD3 | |
| SCHEMBL17740058 | 0.83 | DRD2 (0.36) | HRH4HRH3CHIT1DRD2DRD4 | |
| SCHEMBL19703899 | 0.83 | TTR (0.34) | HRH4HRH3MGLLDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016071856-A1 | AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE | NOVARTIS AG (CH) | 2016-05-12 | — | — | WO | disclosed |