Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | DNM2 | P50570 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604272 | 0.74 | DNM2 (0.38) | TLR7TLR8HRH4HRH3HSD17B10 | |
| SCHEMBL1091252 | 0.70 | HRH3 (0.42) | TLR7TLR8HRH4HRH3TOP2A | |
| SCHEMBL1775054 | 0.66 | NUDT1 (0.43) | TLR7TLR8HRH3 | |
| SCHEMBL1091003 | 0.65 | HRH3 (0.45) | TLR7TLR8HRH4HRH3TOP2A | |
| SCHEMBL1775517 | 0.65 | CHUK (0.45) | TLR7TLR8HRH4HRH3 | |
| SCHEMBL18239931 | 0.65 | HRH3 (0.50) | TLR7TLR8HRH3DNM2NCF1 | |
| SCHEMBL18239956 | 0.65 | HRH3 (0.50) | TLR7TLR8HRH3DNM2NCF1 | |
| SCHEMBL1090160 | 0.64 | HRH3 (0.44) | TLR7TLR8HRH4HRH3DNM2 | |
| SCHEMBL1089442 | 0.64 | HRH3 (0.44) | TLR7TLR8HRH4HRH3DNM2 | |
| SCHEMBL25724042 | 0.63 | HRH3 (0.45) | TLR7TLR8HRH3HSD17B10DNM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |
| US-7943628-B2 | Pyrimidine derivatives | PFIZER LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| US-20070185075-A1 | Pyrimidine derivatives | PFIZER LIMITED | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185075-A1 | Pyrimidine derivatives | TYMS, DPYD, TYMP | TLR7 898/4885TLR8 2312/4885HRH4 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.