Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.66 |
| ▸ | BRD9 | Q9H8M2 | 5/20 | 0.51 |
| ▸ | TAF1 | P21675 | 5/20 | 0.50 |
| ▸ | CECR2 | Q9BXF3 | 4/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.50 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.50 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.50 |
| ▸ | EP300 | Q09472 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.50 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19639059 | 0.87 | BRD4 (0.87) | BRD4BRD9TAF1CECR2TRIM24 | |
| SCHEMBL17748951 | 0.79 | BRD4 (1.00) | BRD4BRD9TAF1CECR2TRIM24 | |
| SCHEMBL17748905 | 0.75 | BRD4 (0.61) | BRD4BRD9TAF1CECR2TRIM24 | |
| SCHEMBL17748890 | 0.74 | CECR2 (0.75) | BRD4BRD9TAF1CECR2TRIM24 | |
| SCHEMBL17748897 | 0.74 | BRD9 (0.69) | BRD4BRD9TAF1CECR2TRIM24 | |
| SCHEMBL17748952 | 0.72 | BRD4 (0.59) | BRD4BRD9TAF1CECR2TRIM24 | |
| SCHEMBL17748899 | 0.71 | BRD4 (1.00) | BRD4BRD9TAF1CECR2TRIM24 | |
| SCHEMBL19869924 | 0.71 | BRD4 (0.95) | BRD4BRD9TAF1CECR2TRIM24 | |
| SCHEMBL17748912 | 0.71 | BRD4 (1.00) | BRD4BRD9TAF1CECR2 | |
| SCHEMBL31590651 | 0.71 | BRD4 (0.66) | BRD4BRD9TAF1CECR2TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218374-A1 | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF BROMODOMAIN | Genentech, Inc. (US) | 2017-09-20 | — | — | EP | claimed |
| WO-2016077380-A1 | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | claimed |