Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 6/20 | 0.69 |
| ▸ | BRD4 | O60885 | 12/20 | 0.66 |
| ▸ | CECR2 | Q9BXF3 | 2/20 | 0.53 |
| ▸ | TAF1 | P21675 | 3/20 | 0.52 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.49 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.49 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.49 |
| ▸ | EP300 | Q09472 | 1/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.49 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17748866 | 0.81 | BRD9 (1.00) | BRD9BRD4CECR2TAF1TRIM24 | |
| SCHEMBL17748912 | 0.80 | BRD4 (1.00) | BRD9BRD4CECR2TAF1 | |
| SCHEMBL17748905 | 0.76 | BRD4 (0.61) | BRD9BRD4CECR2TAF1TRIM24 | |
| SCHEMBL31590651 | 0.74 | BRD4 (0.66) | BRD9BRD4CECR2TAF1TRIM24 | |
| SCHEMBL17748885 | 0.74 | BRD4 (0.66) | BRD9BRD4CECR2TAF1TRIM24 | |
| SCHEMBL17748880 | 0.73 | BRD9 (1.00) | BRD9BRD4CECR2TAF1 | |
| SCHEMBL24866050 | 0.73 | BRD4 (0.76) | BRD9BRD4CECR2TAF1 | |
| SCHEMBL31589809 | 0.72 | CECR2 (0.60) | BRD9BRD4CECR2TAF1TRIM24 | |
| SCHEMBL31590242 | 0.72 | CECR2 (0.60) | BRD9BRD4CECR2TAF1TRIM24 | |
| SCHEMBL17748921 | 0.72 | BRD4 (1.00) | BRD9BRD4CECR2TAF1TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218374-A1 | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF BROMODOMAIN | Genentech, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077380-A1 | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |