Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008518 | 0.85 | GRIN2D (0.59) | MEN1KMT2AFAAH | |
| SCHEMBL28246648 | 0.85 | MEN1 (0.52) | MEN1KMT2AFAAH | |
| SCHEMBL2636547 | 0.85 | MEN1 (0.68) | MEN1KMT2AFAAHCYP2C9CYP2C19 | |
| SCHEMBL19994655 | 0.84 | FAAH (0.45) | CCR3MEN1KMT2AFAAH | |
| SCHEMBL4959434 | 0.84 | ALDH1A1 (0.59) | CCR3MEN1KMT2AFAAHCYP2C9 | |
| SCHEMBL2925616 | 0.84 | MEN1 (0.60) | MEN1KMT2ACYP2C9CYP2C19MAPK14 | |
| SCHEMBL5931753 | 0.84 | TACR3 (0.56) | MEN1KMT2AFAAHCYP2C9CYP2C19 | |
| SCHEMBL15718800 | 0.84 | MEN1 (0.51) | MEN1KMT2AFAAHCCR5CYP2C9 | |
| SCHEMBL27953755 | 0.84 | MEN1 (0.54) | CCR3MEN1KMT2AFAAH | |
| SCHEMBL5169485 | 0.84 | FAAH (0.63) | FAAHCYP2C9CYP2C19MAPK14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310773-B1 | SUBSTITUTED 4-BENZYL AND 4-BENZOYL PIPERIDINE DERIVATIVES | 89BIO LTD (IL) | 2020-12-02 | — | — | EP | disclosed |
| EP-3310773-A1 | SUBSTITUTED 4-BENZYL AND 4-BENZOYL PIPERIDINE DERIVATIVES | Cephalon, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| EP-3218374-A1 | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF BROMODOMAIN | Genentech, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016205590-A1 | SUBSTITUTED 4-BENZYL AND 4-BENZOYL PIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2016-12-22 | — | — | WO | disclosed |
| WO-2016077380-A1 | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |