Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 7/20 | 0.60 |
| ▸ | KCNQ3 | O43525 | 6/20 | 0.60 |
| ▸ | KCNQ4 | P56696 | 3/20 | 0.57 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.57 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17749207 | 0.84 | KCNQ3 (0.56) | KCNQ2KCNQ3KCNQ4KCNQ5APP | |
| SCHEMBL29721496 | 0.83 | APP (0.48) | KCNQ2KCNQ3KCNQ4KCNQ5APP | |
| SCHEMBL20129864 | 0.83 | APP (0.48) | KCNQ2KCNQ3KCNQ4KCNQ5APP | |
| SCHEMBL20129875 | 0.81 | KCNQ2 (0.50) | KCNQ2KCNQ3KCNQ4KCNQ5APP | |
| SCHEMBL17749067 | 0.81 | KCNQ2 (0.75) | KCNQ2KCNQ3KCNQ4KCNQ5APP | |
| SCHEMBL20129861 | 0.81 | BACE1 (0.46) | KCNQ2KCNQ3KDM4EHDAC3HDAC1 | |
| SCHEMBL21496383 | 0.80 | IDO1 (0.44) | KCNQ2KCNQ3KCNQ4KCNQ5KDM4E | |
| SCHEMBL24246362 | 0.80 | KCNQ2 (0.75) | KCNQ2KCNQ3KCNQ4KCNQ5KDM4E | |
| SCHEMBL29721739 | 0.80 | KCNQ2 (0.58) | KCNQ2KCNQ3KCNQ4KCNQ5ALDH1A1 | |
| SCHEMBL20134036 | 0.80 | KCNQ2 (0.58) | KCNQ2KCNQ3KCNQ4KCNQ5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358930-B2 | Selective potassium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-06-14 | — | — | US | disclosed |
| US-11358930-B2 | Selective potassium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-06-14 | — | — | US | disclosed |
| US-11247966-B2 | 4-(p-trifluoromethylbenzyl)-3-fluoro-1,2,4-triphenylamine derivative and pharmaceutical composition and applications thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2022-02-15 | — | — | US | disclosed |
| US-20210238129-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-08-05 | — | — | US | disclosed |
| US-20210238129-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-08-05 | — | — | US | disclosed |
| CN-108707087-B | 4- (p-trifluoromethyl benzyl) -3-fluoro-1, 2,4 triphenylamine derivative, and pharmaceutical composition and application thereof | 河北医科大学 | 2020-10-16 | — | — | CN | disclosed |
| WO-2019203951-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-10-24 | — | — | WO | disclosed |
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-10 | — | — | US | disclosed |
| WO-2016077724-A1 | (2-AMINO-4(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238129-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | KCNH3, KCNH2, KCNJ11 | KCNQ2 35/4885KCNQ3 43/4885KCNQ4 48/4885 |
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | HRH4, H1-10, HDAC10 | KCNQ2 1257/4885KCNQ3 1235/4885KCNQ4 1297/4885 |
| US-11247966-B2 | 4-(p-trifluoromethylbenzyl)-3-fluoro-1,2,4-triphenylamine derivative and pharmaceutical composition and applications thereof | KCNQ1, KCNQ3, KCNQ4 | KCNQ2 4/4885KCNQ3 2/4885KCNQ4 3/4885 |
| US-11358930-B2 | Selective potassium channel agonists | KCNH3, KCNH2, KCNJ11 | KCNQ2 35/4885KCNQ3 43/4885KCNQ4 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.