Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17749207 | 0.86 | KCNQ3 (0.56) | HSD17B10HDAC3NCOR1KCNQ3KCNQ2 | |
| SCHEMBL20129860 | 0.83 | KCNQ3 (0.47) | BACE1HSD17B10IDO1KCNQ3KCNQ2 | |
| SCHEMBL20129875 | 0.83 | KCNQ2 (0.50) | HSD17B10KCNQ3KCNQ2CA12CA1 | |
| SCHEMBL20129870 | 0.82 | KCNQ3 (0.43) | HSD17B10IDO1KCNQ3KCNQ2SMN1; SMN2 | |
| SCHEMBL20133976 | 0.82 | KCNQ3 (0.36) | BACE1HDAC3NCOR1KCNQ3KCNQ2 | |
| SCHEMBL17749144 | 0.81 | KCNQ2 (0.60) | HDAC3KCNQ3KCNQ2KDM4EHDAC1 | |
| SCHEMBL23711052 | 0.79 | KCNQ3 (0.34) | BACE1HDAC3NCOR1KCNQ3KCNQ2 | |
| SCHEMBL29721496 | 0.79 | APP (0.48) | IDO1HDAC3KCNQ3KCNQ2HDAC1 | |
| SCHEMBL17749119 | 0.79 | KCNQ3 (0.34) | BACE1HDAC3NCOR1KCNQ3KCNQ2 | |
| SCHEMBL20129864 | 0.79 | APP (0.48) | IDO1HDAC3KCNQ3KCNQ2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-10 | — | — | US | disclosed |
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | HRH4, H1-10, HDAC10 | BACE1 3768/4885HSD17B10 509/4885IDO1 2185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.