Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | PIR | O00625 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 4/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.45 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2940445 | 1.00 | CYP2C19 (0.84) | CYP2C19KMT2AMEN1PIRALDH1A1 | |
| SCHEMBL1774946 | 1.00 | CYP2C19 (0.84) | CYP2C19KMT2AMEN1PIRALDH1A1 | |
| SCHEMBL16317067 | 0.92 | CYP2C19 (1.00) | CYP2C19KMT2AMEN1PIRALDH1A1 | |
| SCHEMBL17015173 | 0.92 | CYP2C19 (1.00) | CYP2C19KMT2AMEN1PIRALDH1A1 | |
| SCHEMBL17015171 | 0.83 | KMT2A (1.00) | CYP2C19KMT2AMEN1PIRALDH1A1 | |
| SCHEMBL17996453 | 0.83 | KMT2A (1.00) | CYP2C19KMT2AMEN1PIRALDH1A1 | |
| SCHEMBL16317068 | 0.81 | CYP2C19 (0.79) | CYP2C19KMT2AMEN1PIRALDH1A1 | |
| SCHEMBL17020444 | 0.81 | CYP2C19 (0.79) | CYP2C19KMT2AMEN1PIRALDH1A1 | |
| SCHEMBL2937262 | 0.80 | CYP2C19 (0.77) | CYP2C19KMT2AMEN1PIRALDH1A1 | |
| SCHEMBL22217122 | 0.80 | CYP2C19 (0.77) | CYP2C19KMT2AMEN1PIRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943629-B2 | Anticancer/antitumor agents; S-(4-([4-([(1R,2R)-2-Hydroxy-1-methylpropyl]amino)-5-(trifluoromethyl)-pyrimidin-2-yl]amino)phenyl)-S-methyl-N-[(trifluoromethyl)sulphonyl]-sulphimide for example | BAYER SCHERING PHARMA AG (DE) | 2011-05-17 | — | — | US | disclosed |
| EP-2029552-B1 | SULFIMIDES AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AG (DE) | 2010-09-22 | — | — | EP | disclosed |
| EP-2029552-A1 | SULFIMIDES AS PROTEIN KINASE INHIBITORS | Bayer Schering Pharma AG (DE) | 2009-03-04 | — | — | EP | disclosed |
| US-20080058358-A1 | SULPHIMIDES AS PROTEIN KINASE INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2008-03-06 | — | — | US | disclosed |
| WO-2007140957-A1 | SULFIMIDES AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058358-A1 | SULPHIMIDES AS PROTEIN KINASE INHIBITORS | PRKCE, BRAF, PACSIN2 | CYP2C19 3401/4885KMT2A 2144/4885MEN1 2173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.