Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.67 |
| ▸ | PARP1 | P09874 | 4/20 | 0.67 |
| ▸ | F7 | P08709 | 1/20 | 0.67 |
| ▸ | F3 | P13726 | 1/20 | 0.67 |
| ▸ | PPOX | P50336 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | PARP11 | Q9NR21 | 5/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.47 |
| ▸ | VHL | P40337 | 1/20 | 0.45 |
| ▸ | ELOC | Q15369 | 1/20 | 0.45 |
| ▸ | ELOB | Q15370 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1315035 | 0.80 | PARP10 (0.74) | PARP10PARP1F7F3PARP11 | |
| SCHEMBL6977492 | 0.80 | MEN1 (0.58) | PARP10PARP1F7F3PPOX | |
| SCHEMBL793493 | 0.80 | PARP10 (1.00) | PARP10PARP1F7F3PPOX | |
| SCHEMBL6256563 | 0.80 | MEN1 (0.54) | PARP10PARP1F7F3PPOX | |
| SCHEMBL29676942 | 0.80 | PARP10 (1.00) | PARP10PARP1F7F3PPOX | |
| SCHEMBL3296103 | 0.75 | PARP11 (0.64) | PARP10PARP1MEN1KMT2APARP11 | |
| SCHEMBL22451527 | 0.75 | RYR2 (0.56) | PARP10PARP1MEN1KMT2APARP11 | |
| SCHEMBL31743097 | 0.74 | PARP10 (0.81) | PARP10PARP1F7F3PPOX | |
| SCHEMBL19838574 | 0.74 | PARP10 (0.81) | PARP10PARP1F7F3PPOX | |
| SCHEMBL23160447 | 0.74 | PARP10 (0.60) | PARP10PARP1F7F3PPOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218381-B1 | SPIRO-THIAZOLONES | HOFFMANN LA ROCHE (CH) | 2019-01-23 | — | — | EP | disclosed |
| US-10092551-B2 | Spiro-thiazolones | HOFFMANN-LAROCHE INC. (US) | 2018-10-09 | — | — | US | disclosed |
| EP-3218381-A1 | SPIRO-THIAZOLONES | F. Hoffmann-La Roche AG (CH) | 2017-09-20 | — | — | EP | disclosed |
| US-20170246153-A1 | SPIRO-THIAZOLONES | HOFFMANN-LA ROCHE INC. (US) | 2017-08-31 | — | — | US | disclosed |
| WO-2016075181-A1 | SPIRO-THIAZOLONES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10092551-B2 | Spiro-thiazolones | AVPR1A, AVPR2, AVPR1B | PARP10 3503/4885PARP1 3832/4885F7 3301/4885 |
| US-20170246153-A1 | SPIRO-THIAZOLONES | AVPR1A, AVPR2, AVPR1B | PARP10 3503/4885PARP1 3832/4885F7 3301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.