Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP11 | Q9NR21 | 7/20 | 0.64 |
| ▸ | PARP1 | P09874 | 7/20 | 0.64 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.64 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | MPI | P34949 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22313400 | 0.98 | PARP11 (0.62) | PARP11PARP1PARP10PDPK1MAP2K1 | |
| SCHEMBL68581 | 0.78 | MEN1 (0.61) | PARP11PARP1PARP10PDPK1MAP2K1 | |
| SCHEMBL29369705 | 0.78 | PARP10 (1.00) | PARP11PARP1PARP10PDPK1CA12 | |
| SCHEMBL67710 | 0.78 | PARP10 (1.00) | PARP11PARP1PARP10PDPK1CA12 | |
| SCHEMBL4567595 | 0.77 | CA12 (0.61) | PARP11PARP1PARP10PDPK1HPGD | |
| SCHEMBL4455970 | 0.77 | PARP1 (0.57) | PARP11PARP1PARP10PDPK1CASP7 | |
| Hydrochloric Acid SCHEMBL7142299 | 0.77 | MEN1 (0.59) | PARP11PARP1PARP10PDPK1MAP2K1 | |
| Hydrochloric Acid SCHEMBL10647408 | 0.77 | PARP10 (0.96) | PARP11PARP1PARP10PDPK1CA12 | |
| Hydrochloric Acid SCHEMBL29473284 | 0.77 | MEN1 (0.59) | PARP11PARP1PARP10PDPK1MAP2K1 | |
| Hydrochloric Acid SCHEMBL5512697 | 0.77 | MEN1 (0.59) | PARP11PARP1PARP10PDPK1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723384-B2 | Keto lactam compounds and use thereof | ABBOTT GMBH & CO. KG. (DE) | 2010-05-25 | — | — | US | disclosed |
| EP-1692129-B1 | KETO LACTAM COMPOUNDS AND USE THEREOF | ABBOTT GMBH & CO KG (DE) | 2008-08-20 | — | — | EP | disclosed |
| US-7279468-B2 | Integrin ligands | ABBOTT GMBH & CO. KG (DE) | 2007-10-09 | — | — | US | disclosed |
| US-20070219182-A1 | Keto Lactam Compounds and Use Thereof | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2007-09-20 | — | — | US | disclosed |
| EP-1692129-A1 | KETO LACTAM COMPOUNDS AND USE THEREOF | Abbott GmbH & Co. KG (DE) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056546-A1 | KETO LACTAM COMPOUNDS AND USE THEREOF | ABBOTT GMBH & CO. KG (DE) | 2005-06-23 | — | — | WO | disclosed |
| US-6790971-B1 | AMIDE OR CARBAMATE FUNCTION AT 11 BETA-POSITION; CLAIMED 3-ONE-DIENE INTERMEDIATE HAS HYDROXYMETHYLALKYL GROUP ON 11 POSITION; ANTIPROGESTOMIMETIC; HORMONE-DEPENDENT TUMORS; ANIMAL HUSBANDRY | AVENTIS PHARMA S.A. (FR) | 2004-09-14 | — | — | US | disclosed |
| US-20040063934-A1 | Integrin ligands | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2004-04-01 | — | — | US | disclosed |
| EP-1289962-A1 | INTEGRIN LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096312-A1 | INTEGRIN LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 2001-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063934-A1 | Integrin ligands | ITGB3, ITGAV, ITGAL | PARP11 1930/4885PARP1 2372/4885PARP10 1472/4885 |
| US-20070219182-A1 | Keto Lactam Compounds and Use Thereof | OPRD1, DRD3, OPRK1 | PARP11 1768/4885PARP1 2468/4885PARP10 2210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.