Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | MPI | P34949 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.50 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30051842 | 0.89 | GAA (0.44) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL3531650 | 0.89 | GAA (0.44) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL6977492 | 0.85 | MEN1 (0.58) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL31239363 | 0.81 | CES1 (0.48) | MEN1KMT2AGAAPARP10F7 | |
| SCHEMBL17750046 | 0.80 | PARP10 (0.67) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL4000581 | 0.78 | MEN1 (0.54) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL3105252 | 0.78 | MEN1 (0.54) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL6171659 | 0.78 | MEN1 (0.54) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL30274589 | 0.78 | MEN1 (0.54) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL10989615 | 0.78 | ALDH1A1 (0.54) | MEN1KMT2AALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4585867-A | Process for the preparation of 4-quinolinones | RHONE-POULENC SANTE (FR) | 1986-04-29 | — | — | US | claimed |
| EP-0056765-B1 | PREPARATION OF 4-HYDROXYQUINOLINES | RHONE-POULENC SANTE (FR) | 1985-06-19 | — | — | EP | claimed |
| EP-0056763-B1 | PROCESS FOR THE PREPARATION OF 4-QUINOLINONES | RHONE-POULENC SANTE (FR) | 1984-07-04 | — | — | EP | claimed |
| EP-0056766-B1 | PROCESS FOR THE PREPARATION OF 4-AMINO-CHLOROQUINOLINES | RHONE-POULENC SANTE (FR) | 1984-05-16 | — | — | EP | claimed |
| EP-0056764-B1 | PROCESS FOR THE PREPARATION OF 7-CHLORO-1,2,3,4-TETRAHYDRO-4-QUINOLONE | RHONE-POULENC SANTE (FR) | 1983-12-28 | — | — | EP | claimed |
| US-4421920-A | AMINATION, AROMATIZATION, RUTHENIUM CATALYST | RHONE-POULENC SANTE (FR) | 1983-12-20 | — | — | US | claimed |
| US-4421918-A | Process for the preparation of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one | RHONE-POULENC SANTE (FR) | 1983-12-20 | — | — | US | claimed |
| US-4412076-A | Preparation of 4-hydroxyquinolines | RHONE-POULENC SANTE (FR) | 1983-10-25 | — | — | US | claimed |
| US-4412075-A | Process for the preparation of quinolin-4-ones | RHONE-POULENC SANTE (FR) | 1983-10-25 | — | — | US | claimed |
| JP-57171971-A | — | — | None | — | — | JP | disclosed |
| EP-3287441-B1 | ACYLATED 4-AMINOPIPERIDINES AS INHIBITORS OF SERINE PALMITOYLTRANSFERASE | TAKEDA PHARMACEUTICALS CO (JP) | 2021-06-09 | — | — | EP | disclosed |
| CN-107848971-B | Heterocyclic compounds | 武田药品工业株式会社 | 2021-03-26 | — | — | CN | disclosed |
| US-10189785-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICALS COMPANY LIMITED (JP) | 2019-01-29 | — | — | US | disclosed |
| US-20180170874-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-06-21 | — | — | US | disclosed |
| US-4412076-A | Preparation of 4-hydroxyquinolines | RHONE-POULENC SANTE (FR) | 1983-10-25 | — | — | US | disclosed |
| JP-S57171971-A | MANUFACTURE OF 7-CHLORO-1,2,3,4- TETRAHYDROQUINOLINE-4-ONE | RHONE POULENC SANTE | 1982-10-22 | — | — | JP | disclosed |
| EP-0056764-A1 | Process for the preparation of 7-chloro-1,2,3,4-tetrahydro-4-quinolone | RHONE-POULENC SANTE (FR) | 1982-07-28 | — | — | EP | disclosed |
| US-4273775-A | PREVENTION OF OCULAR AND NEURITIC, DIABETIS-ASSOCIATED COMPLICATIONS | PFIZER INC. (US) | 1981-06-16 | — | — | US | disclosed |
| EP-0021704-A1 | Spiro-hydantoin derivatives, process for their preparation and pharmaceutical compositions thereof | PFIZER INC. (US) | 1981-01-07 | — | — | EP | disclosed |
| US-4235911-A | TETRAHYDROQUINOLINE-DERIVED SPIRO-HYDANTOINS, CONTROL OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1980-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189785-B2 | Heterocyclic compound | SPTLC1, SPTLC2, NPC1 | MEN1 1270/4885KMT2A 1530/4885ALDH1A1 2775/4885 |
| US-20180170874-A1 | HETEROCYCLIC COMPOUND | SPTLC1, SPTLC2, NPC1 | MEN1 1270/4885KMT2A 1530/4885ALDH1A1 2775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.