Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1776341 | 0.99 | HTR6 (0.44) | HTR6HTR1AHTR1DHTR1BPRKCI | |
| SCHEMBL1777435 | 0.96 | HTR6 (0.48) | HTR6HTR1AHTR1DHTR1BPRKCI | |
| Hydrochloric Acid SCHEMBL1774375 | 0.95 | HTR6 (0.47) | HTR6HTR1AHTR1DHTR1BPRKCI | |
| SCHEMBL1775615 | 0.87 | HTR6 (0.45) | HTR6HTR1DPRKCIHTR2CNMT1 | |
| SCHEMBL1775896 | 0.87 | HTR6 (0.53) | HTR6HTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL1775901 | 0.87 | HTR6 (0.44) | HTR6HTR1DPRKCIHTR2CNMT1 | |
| Hydrochloric Acid SCHEMBL1773925 | 0.86 | HTR6 (0.52) | HTR6HTR1AHTR2C | |
| SCHEMBL6382957 | 0.86 | HTR6 (0.47) | HTR6HTR2CLMNA | |
| SCHEMBL1776454 | 0.86 | HTR6 (0.50) | HTR6PRKCIHTR2CNMT1LMNA | |
| Hydrochloric Acid SCHEMBL1775284 | 0.85 | HTR6 (0.49) | HTR6PRKCIHTR2CNMT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |