SCHEMBL17752802

SCHEMBL17752802

Cc1nc2cccc(-c3ccccc3)c2c2ccccc12

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.58
ALDH1A1 P00352 3/20 0.49
NUDT1 P36639 2/20 0.49
HPGD P15428 2/20 0.49
CYP1A2 P05177 1/20 0.49
HSD17B10 Q99714 1/20 0.49
PSMB5 P28074 3/20 0.44
KCNH2 Q12809 1/20 0.42
MAPT P10636 2/20 0.42
GAA P10253 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
ADORA2A P29274 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
PDE10A Q9Y233 1/20 0.40
PDCD1 Q15116 1/20 0.40
CD274 Q9NZQ7 1/20 0.40
KDM4E B2RXH2 1/20 0.39
ACACA Q13085 1/20 0.39
DHFR P00374 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17752896 0.79 KDM4E (0.46) ALDH1A1HPGDKCNH2MAPTGAA
SCHEMBL3256104 0.78 GPR3 (0.61) GPR3ALDH1A1NUDT1HPGDCYP1A2
SCHEMBL28311772 0.75 GPR3 (0.57) GPR3ALDH1A1NUDT1HPGDCYP1A2
SCHEMBL85621 0.75 GPR3 (1.00) GPR3ALDH1A1NUDT1HPGDCYP1A2
SCHEMBL29057778 0.75 POLB (0.65) ALDH1A1HPGDCYP1A2KCNH2MAPT
SCHEMBL27961869 0.74 ACHE (0.59) ALDH1A1NUDT1HPGDCYP1A2HSD17B10
SCHEMBL20233977 0.74 CYP1A2 (0.50) GPR3ALDH1A1NUDT1HPGDCYP1A2
SCHEMBL28192105 0.73 ATM (0.41) ALDH1A1HPGDHSD17B10KCNH2MAPT
SCHEMBL21934465 0.73 MEN1 (0.54) ALDH1A1NUDT1HPGDCYP1A2KCNH2
Hydrochloric Acid SCHEMBL3907848 0.73 GPR3 (0.95) GPR3ALDH1A1NUDT1HPGDCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016074755-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2016-05-19 WO disclosed