Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 16/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 9/20 | 0.59 |
| ▸ | SQSTM1 | Q13501 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1776067 | 0.99 | KEAP1 (0.58) | KEAP1NFE2L2SQSTM1GAAMITF | |
| SCHEMBL1775785 | 0.94 | KEAP1 (0.61) | KEAP1NFE2L2SQSTM1GAAMITF | |
| Hydrochloric Acid SCHEMBL1773873 | 0.93 | KEAP1 (0.60) | KEAP1NFE2L2SQSTM1GAAMITF | |
| SCHEMBL1775005 | 0.88 | HKDC1 (0.49) | KEAP1NFE2L2SQSTM1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL1776019 | 0.87 | HKDC1 (0.48) | KEAP1NFE2L2SQSTM1ALDH1A1LMNA | |
| SCHEMBL1777498 | 0.82 | HKDC1 (0.51) | KEAP1NFE2L2SQSTM1ALDH1A1HKDC1 | |
| SCHEMBL1774701 | 0.82 | HKDC1 (0.51) | KEAP1NFE2L2SQSTM1ALDH1A1HKDC1 | |
| SCHEMBL1776585 | 0.82 | HKDC1 (0.51) | KEAP1NFE2L2SQSTM1ALDH1A1HKDC1 | |
| Hydrochloric Acid SCHEMBL1775345 | 0.81 | HKDC1 (0.50) | KEAP1NFE2L2SQSTM1HKDC1 | |
| Hydrochloric Acid SCHEMBL1775351 | 0.81 | HKDC1 (0.50) | KEAP1NFE2L2SQSTM1HKDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |