Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT2 | Q9BWD1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17757120 | 0.92 | PIM1 (0.35) | ACAT2KMT2APDE7ATSHR | |
| SCHEMBL17757109 | 0.91 | ACAT2 (0.36) | ACAT2KMT2APDE7ATSHR | |
| SCHEMBL17757653 | 0.90 | KMT2A (0.41) | ACAT2KMT2APDE7ATSHR | |
| SCHEMBL14398518 | 0.90 | KMT2A (0.41) | ACAT2KMT2APDE7ATSHR | |
| SCHEMBL17757467 | 0.90 | KMT2A (0.41) | ACAT2KMT2APDE7ATSHR | |
| SCHEMBL17757285 | 0.89 | ACAT2 (0.35) | ACAT2 | |
| SCHEMBL17757110 | 0.89 | ACAT2 (0.47) | ACAT2KMT2A | |
| SCHEMBL17757634 | 0.89 | KMT2A (0.39) | ACAT2KMT2APDE7ATSHR | |
| SCHEMBL17757363 | 0.88 | LMNA (0.32) | — | |
| SCHEMBL17757488 | 0.88 | PIK3CB (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016075137-A1 | SPIROPYRAZINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2016-05-19 | — | — | WO | disclosed |