Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT2 | Q9BWD1 | 1/20 | 0.41 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 5/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17757263 | 0.78 | ACAT2 (0.43) | ACAT2 | |
| SCHEMBL17757264 | 0.78 | ACAT2 (0.40) | ACAT2 | |
| SCHEMBL17757275 | 0.75 | ACAT2 (0.41) | ACAT2 | |
| SCHEMBL17757980 | 0.74 | ACAT2 (0.38) | ACAT2 | |
| SCHEMBL17757951 | 0.74 | ACAT2 (0.56) | ACAT2HTR2CSLC6A2SLC6A4 | |
| SCHEMBL17757952 | 0.74 | ACAT2 (0.56) | ACAT2HTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL21982537 | 0.72 | ACAT2 (0.54) | ACAT2HTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL17757267 | 0.72 | ACAT2 (0.53) | ACAT2HTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL17757274 | 0.70 | ACAT2 (0.54) | ACAT2HTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL17757949 | 0.70 | ACAT2 (0.43) | ACAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016075137-A1 | SPIROPYRAZINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2016-05-19 | — | — | WO | disclosed |