Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT2 | Q9BWD1 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 9/20 | 0.33 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HTR1E | P28566 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17757951 | 0.88 | ACAT2 (0.56) | ACAT2KMT2AHTR6HTR2AHTR1A | |
| SCHEMBL17757977 | 0.88 | ACAT2 (0.50) | ACAT2KMT2AHTR6HTR2AMEN1 | |
| SCHEMBL17757279 | 0.88 | ACAT2 (0.50) | ACAT2KMT2AHTR6MEN1GAA | |
| SCHEMBL17757952 | 0.86 | ACAT2 (0.56) | ACAT2KMT2AHTR6HTR2AHTR1A | |
| SCHEMBL17757267 | 0.85 | ACAT2 (0.53) | ACAT2KMT2AHTR6HTR2AHTR1A | |
| SCHEMBL17757970 | 0.84 | ACAT2 (0.46) | ACAT2KMT2AMEN1GAACHRM1 | |
| SCHEMBL17757979 | 0.80 | ACAT2 (0.42) | ACAT2KMT2AHTR6DRD2MEN1 | |
| SCHEMBL17757958 | 0.80 | ACAT2 (0.42) | ACAT2KMT2AMEN1 | |
| SCHEMBL17757948 | 0.79 | ACAT2 (0.47) | ACAT2KMT2AMEN1SIGMAR1 | |
| SCHEMBL17757960 | 0.78 | ACAT2 (0.39) | ACAT2KMT2AMEN1GAASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647687-B2 | Spiropyrazine derivatives as inhibitors of non-apoptotic regulated cell-death | HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH) (DE) | 2020-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647687-B2 | Spiropyrazine derivatives as inhibitors of non-apoptotic regulated cell-death | AIFM2, BAD, AIFM1 | ACAT2 1935/4885KMT2A 4518/4885HTR6 1352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.