Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 8/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 8/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 8/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 8/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 8/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30818752 | 0.77 | HRH4 (0.49) | HRH4HRH3HRH2 | |
| SCHEMBL1774244 | 0.76 | HRH4 (0.56) | HRH4PRMT5WDR77HRH3HRH2 | |
| SCHEMBL29501475 | 0.73 | HRH4 (0.52) | HRH4SCN9APRMT5WDR77ADRA1A | |
| SCHEMBL26248522 | 0.72 | HRH4 (0.51) | HRH4SCN9APRMT5WDR77ADRA1A | |
| SCHEMBL25120330 | 0.72 | PRMT5 (0.64) | PRMT5WDR77 | |
| SCHEMBL29501464 | 0.72 | PRMT5 (0.50) | PRMT5WDR77 | |
| SCHEMBL26254803 | 0.72 | HRH4 (0.50) | HRH4SCN9APRMT5WDR77ADRA1A | |
| SCHEMBL29501378 | 0.72 | HRH4 (0.50) | HRH4SCN9APRMT5WDR77ADRA1A | |
| SCHEMBL20576716 | 0.71 | HRH3 (0.66) | HRH4HRH3HRH2 | |
| SCHEMBL20576715 | 0.71 | HRH3 (0.66) | HRH4HRH3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |
| CN-101341134-B | Pyrimidine derivatives | PFIZER LTD | 2013-05-01 | — | — | CN | disclosed |
| US-7943628-B2 | Pyrimidine derivatives | PFIZER LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| EP-1966162-A2 | PYRIMIDINE DERIVATIVES | Pfizer Limited (GB) | 2008-09-10 | — | — | EP | disclosed |
| US-20070185075-A1 | Pyrimidine derivatives | PFIZER LIMITED | 2007-08-09 | — | — | US | disclosed |
| WO-2007072163-A2 | PYRIMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185075-A1 | Pyrimidine derivatives | TYMS, DPYD, TYMP | HRH4 184/4885SCN9A 4011/4885PRMT5 474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.