Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.66 |
| ▸ | HTR1A | P08908 | 5/20 | 0.66 |
| ▸ | HTR1D | P28221 | 5/20 | 0.66 |
| ▸ | HTR1B | P28222 | 5/20 | 0.66 |
| ▸ | NCF1 | P14598 | 6/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1774737 | 0.99 | HTR6 (0.65) | HTR6HTR1AHTR1DHTR1BNCF1 | |
| SCHEMBL1776431 | 0.90 | HTR6 (0.73) | HTR6HTR1AHTR1DHTR1BNCF1 | |
| Hydrochloric Acid SCHEMBL1775609 | 0.89 | HTR6 (0.72) | HTR6HTR1AHTR1DHTR1BNCF1 | |
| SCHEMBL1776645 | 0.86 | HTR6 (0.68) | HTR6HTR1AHTR1DHTR1BNCF1 | |
| Hydrochloric Acid SCHEMBL1776195 | 0.85 | HTR6 (0.67) | HTR6HTR1AHTR1DHTR1BNCF1 | |
| SCHEMBL1775791 | 0.83 | HTR6 (0.59) | HTR6HTR1AHTR1DHTR1BNCF1 | |
| Hydrochloric Acid SCHEMBL1775070 | 0.82 | HTR6 (0.58) | HTR6HTR1AHTR1DHTR1BNCF1 | |
| SCHEMBL1774985 | 0.81 | HTR6 (0.66) | HTR6HTR1AHTR1DHTR1BNCF1 | |
| Hydrochloric Acid SCHEMBL1775996 | 0.81 | NCF1 (0.61) | HTR6HTR1AHTR1DHTR1BNCF1 | |
| Hydrochloric Acid SCHEMBL1775184 | 0.80 | HTR6 (0.65) | HTR6HTR1AHTR1DHTR1BNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |