Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 14/20 | 0.42 |
| ▸ | DRD2 | P14416 | 13/20 | 0.42 |
| ▸ | HTR7 | P34969 | 12/20 | 0.42 |
| ▸ | HTR6 | P50406 | 11/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1775921 | 0.99 | GUSB (0.42) | GUSBHTR2ADRD2HTR7HTR6 | |
| SCHEMBL1774492 | 0.90 | GUSB (0.54) | GUSBHTR2ADRD2HTR7HTR6 | |
| Hydrochloric Acid SCHEMBL1775163 | 0.89 | GUSB (0.53) | GUSBHTR2ADRD2HTR7HTR6 | |
| SCHEMBL1774424 | 0.86 | GBA1 (0.42) | GUSB | |
| SCHEMBL1774595 | 0.81 | TSHR (0.43) | — | |
| Hydrochloric Acid SCHEMBL1776278 | 0.80 | TSHR (0.42) | — | |
| SCHEMBL1775535 | 0.78 | FLT3 (0.46) | GUSBHTR2ADRD2HTR7HTR6 | |
| SCHEMBL1775401 | 0.77 | HRH4 (0.45) | HTR2ADRD2HTR7HTR6HRH4 | |
| Hydrochloric Acid SCHEMBL1773881 | 0.77 | FLT3 (0.45) | GUSBHTR2ADRD2HTR7HTR6 | |
| Hydrochloric Acid SCHEMBL1774702 | 0.77 | HRH4 (0.44) | HTR2ADRD2HTR7HTR6HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |