Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.33 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31240238 | 0.88 | HTR2C (0.42) | HPGDRAB9AALDH1A1HSD17B10HRH3 | |
| SCHEMBL17711525 | 0.86 | HPGD (0.47) | HPGDRAB9AALDH1A1HSD17B10HTR2C | |
| SCHEMBL28176249 | 0.84 | HTR2C (0.52) | HPGDRAB9AHRH3HTR2C | |
| SCHEMBL28580100 | 0.79 | MAPT (0.41) | HPGDRAB9AALDH1A1HSD17B10HRH3 | |
| SCHEMBL17711415 | 0.78 | HPGD (0.40) | HPGDRAB9AALDH1A1HSD17B10HTR2C | |
| SCHEMBL2745784 | 0.74 | HTR2B (0.49) | RAB9AALDH1A1HRH3HTR2BKMT2A | |
| SCHEMBL12169124 | 0.71 | HTR2B (0.50) | ALDH1A1HTR2BCYP2C19ACHE | |
| SCHEMBL17076771 | 0.71 | HTR2B (0.35) | HRH3HTR2BCYP2C19ACHE | |
| SCHEMBL15012294 | 0.70 | HTR2C (0.53) | HPGDRAB9AHRH3HTR2C | |
| SCHEMBL12188683 | 0.70 | SCD5 (0.44) | HRH3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212643-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | Janssen Pharmaceutica, N.V. (BE) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016069974-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2016-05-06 | — | — | WO | disclosed |