Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | HTR6 | P50406 | 10/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1776291 | 0.99 | HTR6 (0.43) | HTR2CHTR6EPHX2NCF1HTR1A | |
| SCHEMBL1775158 | 0.86 | HTR2C (0.44) | HTR2CHTR6HTR1ADRD2HTR1D | |
| Hydrochloric Acid SCHEMBL1775915 | 0.85 | HTR6 (0.43) | HTR2CHTR6HTR1ADRD2HTR1D | |
| SCHEMBL1776940 | 0.85 | CYP2C19 (0.43) | HTR2CHTR6NCF1DRD2 | |
| SCHEMBL1774794 | 0.85 | HTR2C (0.55) | HTR2CHTR6HTR1ADRD2HTR1D | |
| Hydrochloric Acid SCHEMBL1775567 | 0.84 | CYP2C19 (0.43) | HTR2CHTR6NCF1DRD2 | |
| Hydrochloric Acid SCHEMBL1774267 | 0.84 | HTR2C (0.54) | HTR2CHTR6HTR1ADRD2HTR1D | |
| SCHEMBL1775605 | 0.83 | HTR6 (0.56) | HTR2CHTR6HTR1ADRD2 | |
| SCHEMBL1777435 | 0.83 | HTR6 (0.48) | HTR2CHTR6HTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL1775612 | 0.82 | HTR6 (0.55) | HTR2CHTR6HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |