⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22857328 | 0.79 | — | — | |
| SCHEMBL17689313 | 0.79 | NLRP3 (0.37) | — | |
| SCHEMBL16928602 | 0.78 | — | — | |
| SCHEMBL14982551 | 0.76 | — | — | |
| SCHEMBL17946083 | 0.76 | RECQL (0.33) | — | |
| SCHEMBL16248657 | 0.76 | NLRP3 (0.32) | — | |
| SCHEMBL23419843 | 0.74 | NLRP3 (0.33) | — | |
| SCHEMBL16588358 | 0.72 | — | — | |
| SCHEMBL26848358 | 0.71 | CYP1A2 (0.32) | — | |
| SCHEMBL1500279 | 0.70 | ALDH1A1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240383938-A1 | PHOSPHOROAMIDATE ESTERS, AND USE AND SYNTHESIS THEREOF | ROCHE SEQUENCING SOLUTIONS INC (US) | 2024-11-21 | — | — | US | disclosed |
| US-20220073556-A1 | PHOSPHOROAMIDATE ESTERS, AND USE AND SYNTHESIS THEREOF | Roche Sequencing Solutions, Inc. | 2022-03-10 | — | — | US | disclosed |
| US-10774105-B2 | Phosphoroamidate esters, and use and synthesis thereof | STRATOS GENOMICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-10774105-B2 | Phosphoroamidate esters, and use and synthesis thereof | STRATOS GENOMICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190330254-A1 | PHOSPHOROAMIDATE ESTERS, AND USE AND SYNTHESIS THEREOF | Roche Sequencing Solutions, Inc. | 2019-10-31 | — | — | US | disclosed |
| US-20190330254-A1 | PHOSPHOROAMIDATE ESTERS, AND USE AND SYNTHESIS THEREOF | Roche Sequencing Solutions, Inc. | 2019-10-31 | — | — | US | disclosed |
| US-10301345-B2 | Phosphoroamidate esters, and use and synthesis thereof | STRATOS GENOMICS, INC. (US) | 2019-05-28 | — | — | US | disclosed |
| US-10301345-B2 | Phosphoroamidate esters, and use and synthesis thereof | STRATOS GENOMICS, INC. (US) | 2019-05-28 | — | — | US | disclosed |
| EP-3221327-A1 | NULCEOSIDE PHOSPHOROAMIDATE ESTERS AND DERIVATIVES THEREOF, USE AND SYNTHESIS THEREOF | Stratos Genomics, Inc. (US) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016081871-A1 | NULCEOSIDE PHOSPHOROAMIDATE ESTERS AND DERIVATIVES THEREOF, USE AND SYNTHESIS THEREOF | STRATOS GENOMICS, INC. (US) | 2016-05-26 | — | — | WO | disclosed |
| US-20160145292-A1 | PHOSPHOROAMIDATE ESTERS, AND USE AND SYNTHESIS THEREOF | Roche Sequencing Solutions, Inc. | 2016-05-26 | — | — | US | disclosed |
| US-20160145292-A1 | PHOSPHOROAMIDATE ESTERS, AND USE AND SYNTHESIS THEREOF | Roche Sequencing Solutions, Inc. | 2016-05-26 | — | — | US | disclosed |
| US-20160145292-A1 | PHOSPHOROAMIDATE ESTERS, AND USE AND SYNTHESIS THEREOF | Roche Sequencing Solutions, Inc. | 2016-05-26 | — | — | US | disclosed |