Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 16/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754297 | 1.00 | WNT3A (0.43) | WNT3AKITPSEN1PSEN2APH1B | |
| SCHEMBL17618706 | 0.92 | HTR2C (0.41) | WNT3A | |
| SCHEMBL19689778 | 0.92 | HTR2C (0.41) | WNT3A | |
| SCHEMBL16754671 | 0.92 | HRH3 (0.38) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL16754574 | 0.91 | WNT3A (0.41) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17778222 | 0.91 | WNT3A (0.41) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL16754500 | 0.90 | IRAK4 (0.37) | WNT3AKITPSEN1PSEN2APH1B | |
| SCHEMBL17618695 | 0.89 | BTK (0.39) | WNT3A | |
| SCHEMBL16754293 | 0.89 | PRMT5 (0.38) | WNT3AKITABL1 | |
| SCHEMBL17770596 | 0.89 | PRMT5 (0.38) | WNT3AKITABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221312-A2 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline LLC (US) | 2017-09-27 | — | — | EP | disclosed |
| EP-3221316-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016081692-A2 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-26 | — | — | WO | disclosed |
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |