Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 11/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754574 | 1.00 | WNT3A (0.41) | WNT3AROCK1CDC42BPBPSEN1PSEN2 | |
| SCHEMBL16754671 | 0.92 | HRH3 (0.38) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17768108 | 0.91 | WNT3A (0.43) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL16754297 | 0.91 | WNT3A (0.43) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17618706 | 0.89 | HTR2C (0.41) | WNT3A | |
| SCHEMBL19689778 | 0.89 | HTR2C (0.41) | WNT3A | |
| SCHEMBL16754500 | 0.89 | IRAK4 (0.37) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17618695 | 0.87 | BTK (0.39) | WNT3ALRRK2JAK1TYK2 | |
| SCHEMBL17770584 | 0.87 | ABL1 (0.36) | WNT3AROCK1CDC42BPBABL1USP30 | |
| SCHEMBL17770596 | 0.87 | PRMT5 (0.38) | WNT3AABL1USP30GRM5HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016081692-A2 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-26 | — | — | WO | disclosed |