Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.34 |
| ▸ | RAF1 | P04049 | 7/20 | 0.34 |
| ▸ | BRAF | P15056 | 7/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754540 | 0.86 | KDM4E (0.38) | KDM4EL3MBTL1MEN1USP2KMT2A | |
| SCHEMBL16754697 | 0.75 | KDM4E (0.49) | KDM4EL3MBTL1SHMT2NPC1TP53 | |
| SCHEMBL16754622 | 0.75 | HTR2C (0.40) | ALDH1A1HTR2CHTR2A | |
| SCHEMBL16754375 | 0.73 | HTR2C (0.41) | ALDH1A1HTR2CHTR2A | |
| SCHEMBL17768108 | 0.73 | WNT3A (0.43) | ABL1 | |
| SCHEMBL16754297 | 0.73 | WNT3A (0.43) | ABL1 | |
| SCHEMBL16754601 | 0.73 | KDM4E (0.46) | KDM4EL3MBTL1SHMT2NPC1TP53 | |
| SCHEMBL16754539 | 0.72 | HTR2C (0.40) | ABL1KDM4ENPC1TP53RAB9A | |
| SCHEMBL17618699 | 0.72 | NAMPT (0.46) | KDM4ENPC1TP53RAB9AALDH1A1 | |
| SCHEMBL19699694 | 0.72 | KDM4E (0.47) | KDM4EL3MBTL1BRAFNPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221316-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |