Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 15/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17768219 | 1.00 | CALCRL (0.37) | CALCRLUSP30IRAK4 | |
| SCHEMBL22239649 | 0.88 | CALCRL (0.37) | CALCRL | |
| SCHEMBL19689823 | 0.86 | CALCRL (0.37) | CALCRLIRAK4 | |
| SCHEMBL17768095 | 0.84 | ABL1 (0.37) | USP30IRAK4 | |
| SCHEMBL17767957 | 0.84 | ABL1 (0.37) | USP30IRAK4 | |
| SCHEMBL17768178 | 0.84 | ABL1 (0.37) | USP30IRAK4 | |
| SCHEMBL16754671 | 0.83 | HRH3 (0.38) | USP30 | |
| SCHEMBL17770120 | 0.82 | CALCRL (0.36) | CALCRL | |
| SCHEMBL17767975 | 0.82 | WNT3A (0.35) | USP30 | |
| SCHEMBL19699123 | 0.82 | FGFR4 (0.35) | USP30IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221316-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |