Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.35 |
| ▸ | WNT3A | P56704 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17767957 | 1.00 | ABL1 (0.37) | ABL1NTRK1MAPK1USP30WNT3A | |
| SCHEMBL17768095 | 1.00 | ABL1 (0.37) | ABL1NTRK1MAPK1USP30WNT3A | |
| SCHEMBL16754282 | 0.91 | KARS1 (0.40) | ABL1MAPK1WNT3AMTORGSK3B | |
| SCHEMBL17778323 | 0.91 | KARS1 (0.40) | ABL1MAPK1WNT3AMTORGSK3B | |
| SCHEMBL17778911 | 0.89 | ABL1 (0.36) | ABL1MAPK1USP30WNT3AMTOR | |
| SCHEMBL19689785 | 0.89 | ABL1 (0.36) | ABL1MAPK1USP30WNT3AMTOR | |
| SCHEMBL17618509 | 0.89 | WNT3A (0.41) | ABL1WNT3AGSK3B | |
| SCHEMBL19689811 | 0.88 | DYRK1A (0.42) | ABL1MAPK1USP30WNT3AMTOR | |
| SCHEMBL17778888 | 0.88 | PIM1 (0.38) | ABL1MAPK1WNT3AMTOR | |
| SCHEMBL17778803 | 0.88 | DYRK1A (0.42) | ABL1MAPK1USP30WNT3AMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221316-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |