Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1774370 | 0.99 | HTR6 (0.56) | HTR6CYP1A2CYP3A4USP2CYP2C19 | |
| SCHEMBL1775410 | 0.89 | HTR6 (0.48) | HTR6CYP1A2CYP3A4USP2CYP2C19 | |
| Hydrochloric Acid SCHEMBL1776185 | 0.88 | HTR6 (0.47) | HTR6CYP1A2CYP3A4USP2CYP2C19 | |
| SCHEMBL1775605 | 0.86 | HTR6 (0.56) | HTR6HTR2CHTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL1775612 | 0.85 | HTR6 (0.55) | HTR6HTR2CHTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL5013081 | 0.84 | HTR6 (0.54) | HTR6CYP1A2CYP3A4CYP2C19ADRB1 | |
| SCHEMBL1774912 | 0.84 | HTR6 (0.43) | HTR6CYP1A2CYP3A4USP2CYP2C19 | |
| Hydrochloric Acid SCHEMBL1774669 | 0.83 | HTR6 (0.42) | HTR6CYP1A2CYP3A4USP2CYP2C19 | |
| SCHEMBL1777100 | 0.82 | HTR6 (0.46) | HTR6CYP1A2CYP3A4USP2CYP2C19 | |
| SCHEMBL1775896 | 0.82 | HTR6 (0.53) | HTR6HTR2CHTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |
| EP-1513828-A1 | NEW COMPOUNDS USEFUL FOR THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS DISORDERS | Biovitrum AB (SE) | 2005-03-16 | — | — | EP | disclosed |
| WO-2004000828-A1 | NEW COMPOUNDS USEFUL FOR THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS DISORDERS | BIOVITRUM AB (SE) | 2003-12-31 | — | — | WO | disclosed |