Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CHRND | Q07001 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775564 | 0.89 | HTR6 (0.44) | HTR6USP2HSD17B10DRD2TSHR | |
| SCHEMBL1775382 | 0.84 | HTR6 (0.45) | HTR6CYP1A2CYP3A4USP2CYP2C19 | |
| SCHEMBL1775766 | 0.84 | HTR2C (0.40) | HTR6USP2HSD17B10CLK4DRD2 | |
| SCHEMBL1776873 | 0.82 | HTR6 (0.57) | HTR6CYP1A2CYP3A4USP2CYP2C19 | |
| Hydrochloric Acid SCHEMBL1774370 | 0.82 | HTR6 (0.56) | HTR6CYP1A2CYP3A4USP2CYP2C19 | |
| Hydrochloric Acid SCHEMBL5012454 | 0.81 | HTR2C (0.39) | HTR6USP2HSD17B10CLK4DRD2 | |
| Hydrochloric Acid SCHEMBL1775164 | 0.79 | HTR2C (0.37) | HTR6USP2HSD17B10CLK4DRD2 | |
| SCHEMBL1775410 | 0.78 | HTR6 (0.48) | HTR6CYP1A2CYP3A4USP2CYP2C19 | |
| Hydrochloric Acid SCHEMBL1776185 | 0.77 | HTR6 (0.47) | HTR6CYP1A2CYP3A4USP2CYP2C19 | |
| SCHEMBL1774912 | 0.76 | HTR6 (0.43) | HTR6CYP1A2CYP3A4USP2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| EP-1897881-A2 | Compounds useful for the treatment of obesity, type II diabetes and CNS disorders | Biovitrum AB (publ) (SE) | 2008-03-12 | — | — | EP | disclosed |