Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 5/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.31 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17769327 | 1.00 | KIF11 (0.33) | KIF11BTKTRPV1KCNJ5KCNJ3 | |
| SCHEMBL17769709 | 1.00 | KIF11 (0.33) | KIF11BTKTRPV1KCNJ5KCNJ3 | |
| SCHEMBL17769398 | 1.00 | KIF11 (0.33) | KIF11BTKTRPV1KCNJ5KCNJ3 | |
| SCHEMBL17769396 | 1.00 | KIF11 (0.33) | KIF11BTKTRPV1KCNJ5KCNJ3 | |
| SCHEMBL19706579 | 0.96 | KIF18A (0.33) | BTKTRPV1KCNJ5KCNJ3KIF18A | |
| SCHEMBL17768054 | 0.96 | KIF18A (0.33) | BTKTRPV1KCNJ5KCNJ3KIF18A | |
| SCHEMBL17768245 | 0.96 | KIF18A (0.33) | BTKTRPV1KCNJ5KCNJ3KIF18A | |
| SCHEMBL17778686 | 0.96 | KIF18A (0.33) | BTKTRPV1KCNJ5KCNJ3KIF18A | |
| SCHEMBL17768159 | 0.96 | KIF18A (0.33) | BTKTRPV1KCNJ5KCNJ3KIF18A | |
| SCHEMBL17769323 | 0.94 | KIF11 (0.34) | KIF11BTKTRPV1KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221322-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079711-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |