Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17778466 | 1.00 | DPP4 (0.41) | DPP4DPP7TRPV4TACR2TACR3 | |
| SCHEMBL17769661 | 0.88 | IRAK4 (0.39) | KCNH2IRAK4ALDH1A1CYP2C19KDM4E | |
| SCHEMBL20550603 | 0.88 | ALDH1A1 (0.47) | KCNH2IRAK4ALDH1A1CYP2C19NPSR1 | |
| SCHEMBL17778371 | 0.88 | ALDH1A1 (0.45) | KCNH2IRAK4ALDH1A1CYP2C19KDM4E | |
| SCHEMBL20550479 | 0.88 | ALDH1A1 (0.42) | KCNH2IRAK4ALDH1A1CYP2C19NPSR1 | |
| SCHEMBL17618383 | 0.86 | CNR2 (0.41) | DPP4DPP7TRPV4TACR2TACR3 | |
| SCHEMBL17769468 | 0.85 | ALDH1A1 (0.43) | KCNH2ALDH1A1CYP2C19KDM4ECYP2C9 | |
| SCHEMBL17769507 | 0.85 | ALDH1A1 (0.43) | KCNH2ALDH1A1CYP2C19KDM4ECYP2C9 | |
| SCHEMBL17778498 | 0.84 | PHGDH (0.41) | TRPV1ALDH1A1CYP2C19NPSR1KDM4E | |
| SCHEMBL17778423 | 0.81 | KDM4E (0.42) | KCNH2TRPV1ALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3220918-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079712-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |