Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | PHGDH | O43175 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CPT2 | P23786 | 1/20 | 0.37 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17769511 | 1.00 | KDM4E (0.42) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17778498 | 0.95 | PHGDH (0.41) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17769364 | 0.88 | KDM4E (0.42) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL19365675 | 0.88 | KDM4E (0.42) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17618904 | 0.88 | KDM4E (0.42) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17769468 | 0.86 | ALDH1A1 (0.43) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17769507 | 0.86 | ALDH1A1 (0.43) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17778549 | 0.86 | KDM4E (0.41) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17778333 | 0.85 | KIF11 (0.37) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17778332 | 0.84 | KIF11 (0.37) | KDM4ELMNAHSD17B10USP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079712-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |