Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 17/20 | 0.74 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.67 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777038 | 0.90 | ENPP2 (0.73) | GABRA5ENPP2GABRA1 | |
| SCHEMBL1778260 | 0.89 | GABRA5 (0.73) | GABRA5ENPP2GABRA1 | |
| SCHEMBL1776578 | 0.87 | ENPP2 (0.66) | GABRA5ENPP2GABRA1 | |
| SCHEMBL2922020 | 0.86 | ENPP2 (0.67) | GABRA5ENPP2 | |
| SCHEMBL2931408 | 0.85 | GABRA5 (1.00) | GABRA5 | |
| SCHEMBL1778361 | 0.84 | GABRA5 (0.77) | GABRA5ENPP2GABRA1 | |
| SCHEMBL1775811 | 0.84 | GABRA5 (0.66) | GABRA5ENPP2 | |
| SCHEMBL1776634 | 0.83 | GABRA5 (0.77) | GABRA5GABRA1 | |
| SCHEMBL14894754 | 0.80 | ENPP2 (1.00) | GABRA5ENPP2 | |
| SCHEMBL1777214 | 0.78 | GABRA5 (0.60) | GABRA5ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | claimed |
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | disclosed |