Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 6/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4324752 | 0.79 | ALDH1A1 (0.43) | TSHRHSD17B10CYP2A6KDM1ARCOR1 | |
| SCHEMBL18898525 | 0.76 | RECQL (0.41) | POLBKDM1ARCOR1GAAHSD11B1 | |
| SCHEMBL10975565 | 0.75 | CHRNA7 (0.47) | KDM1AMAOBALDH1A1CYP2C19MEN1 | |
| SCHEMBL17346807 | 0.73 | GAA (0.37) | TSHRPOLBHSD17B10CYP2A6KDM1A | |
| SCHEMBL16819947 | 0.73 | HSD17B10 (0.38) | TSHRPOLBHSD17B10CYP2A6KDM1A | |
| SCHEMBL15559251 | 0.73 | GAA (0.37) | TSHRPOLBHSD17B10CYP2A6KDM1A | |
| SCHEMBL16841716 | 0.73 | HSD17B10 (0.38) | TSHRPOLBHSD17B10CYP2A6KDM1A | |
| SCHEMBL16819998 | 0.73 | GAA (0.37) | TSHRPOLBHSD17B10CYP2A6KDM1A | |
| SCHEMBL15442881 | 0.71 | SLC9A1 (0.45) | TSHRHSD17B10LMNAKMT2A | |
| SCHEMBL15442883 | 0.71 | SLC9A1 (0.45) | TSHRHSD17B10LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670731-B1 | POSITIVE ALLOSTERIC MODULATORS OF THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AND USES THEREOF. | BIONOMICS LTD (AU) | 2016-05-25 | — | — | EP | disclosed |