Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 14/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | GLA | P06280 | 4/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HBB | P68871 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21142123 | 0.86 | TOP1 (0.52) | TOP1ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL17779620 | 0.84 | TOP1 (0.51) | TOP1ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL22596800 | 0.84 | TOP1 (0.51) | TOP1ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL5803265 | 0.84 | TOP1 (0.62) | TOP1ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL5803262 | 0.84 | TOP1 (0.62) | TOP1ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL25932514 | 0.82 | TOP1 (0.58) | TOP1ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL17775406 | 0.79 | TOP1 (0.61) | TOP1ALDH1A1KDM4ESMN1; SMN2GLA | |
| SCHEMBL15149692 | 0.79 | TOP1 (0.58) | TOP1ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL17775409 | 0.78 | TOP1 (0.60) | TOP1ALDH1A1KDM4ESMN1; SMN2GLA | |
| SCHEMBL15080455 | 0.76 | TOP1 (0.55) | TOP1ALDH1A1HPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160143900-A1 | CAMPTOTHECIN DERIVATIVES AS ANTI-HIV AGENTS AND METHODS OF IDENTIFYING AGENTS THAT DISRUPT VIF SELF-ASSOCIATION | OYAGEN, INC. (US) | 2016-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160143900-A1 | CAMPTOTHECIN DERIVATIVES AS ANTI-HIV AGENTS AND METHODS OF IDENTIFYING AGENTS THAT DISRUPT VIF SELF-ASSOCIATION | REV1, APOBEC3A, TOP2A | TOP1 11/4885ALDH1A1 1625/4885HPGD 2721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.