Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 19/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17770220 | 1.00 | OPRK1 (0.39) | OPRK1GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL17769289 | 0.95 | OPRK1 (0.37) | OPRK1GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL17776946 | 0.91 | NTRK1 (0.34) | OPRK1GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL17776993 | 0.90 | KDM4E (0.36) | OPRK1GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL17770426 | 0.90 | KDM4E (0.36) | OPRK1GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL22239707 | 0.89 | CNR2 (0.35) | OPRK1GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL17777017 | 0.87 | GAA (0.32) | OPRK1GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL17770379 | 0.87 | PIK3C3 (0.34) | GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL17769757 | 0.87 | OPRK1 (0.42) | OPRK1OPRM1OPRD1 | |
| SCHEMBL17769352 | 0.87 | OPRK1 (0.42) | OPRK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |
| WO-2016079710-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |