Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.40 |
| ▸ | GRM5 | P41594 | 5/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754383 | 1.00 | NTRK1 (0.40) | NTRK1GRM5NAMPTCNR2SCN9A | |
| SCHEMBL22239713 | 0.95 | NTRK1 (0.41) | NTRK1GRM5NAMPTACKR3 | |
| SCHEMBL16754440 | 0.95 | NTRK1 (0.41) | NTRK1GRM5NAMPTACKR3 | |
| SCHEMBL17777053 | 0.91 | GRM5 (0.42) | GRM5 | |
| SCHEMBL19714365 | 0.91 | ALDH1A1 (0.42) | GRM5 | |
| SCHEMBL16754631 | 0.91 | GRM5 (0.42) | GRM5 | |
| SCHEMBL19670604 | 0.90 | NTRK1 (0.39) | NTRK1GRM5CNR2ACKR3 | |
| SCHEMBL16754328 | 0.90 | NTRK1 (0.39) | NTRK1GRM5CNR2ACKR3 | |
| SCHEMBL19714249 | 0.90 | MAPT (0.43) | GRM5 | |
| SCHEMBL16754448 | 0.89 | DRD2 (0.39) | NTRK1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |
| WO-2016079710-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |