Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17768096 | 1.00 | VCP (0.39) | VCPCHRM4GSK3BDYRK1AMAP3K5 | |
| SCHEMBL17778763 | 0.92 | GSK3B (0.39) | VCPCHRM4GSK3BDYRK1AMAP3K5 | |
| SCHEMBL17767967 | 0.92 | GSK3B (0.39) | VCPCHRM4GSK3BDYRK1AMAP3K5 | |
| SCHEMBL17778647 | 0.91 | GSK3B (0.38) | VCPCHRM4GSK3BDYRK1ATRPV1 | |
| SCHEMBL17768123 | 0.91 | MALT1 (0.39) | GSK3BDYRK1AMALT1GRM5 | |
| SCHEMBL17767922 | 0.90 | MAPK1 (0.38) | MAP3K5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL17778718 | 0.90 | MAPK1 (0.38) | MAP3K5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL17767930 | 0.87 | HTR2A (0.39) | CHRM4 | |
| SCHEMBL17618510 | 0.86 | PIK3CA (0.41) | VCPGSK3BDYRK1ATRPV1NTRK1 | |
| SCHEMBL17778459 | 0.85 | GSK3B (0.38) | VCPGSK3BDYRK1ATRPV1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |