Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 2/20 | 0.36 |
| ▸ | WNT3A | P56704 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17767967 | 1.00 | GSK3B (0.39) | GSK3BDYRK1AABL1GRM5NTRK1 | |
| SCHEMBL17778337 | 0.92 | VCP (0.39) | GSK3BDYRK1AABL1GRM5NTRK1 | |
| SCHEMBL17768096 | 0.92 | VCP (0.39) | GSK3BDYRK1AABL1GRM5NTRK1 | |
| SCHEMBL17778647 | 0.92 | GSK3B (0.38) | GSK3BDYRK1AABL1GRM5NTRK1 | |
| SCHEMBL17768123 | 0.92 | MALT1 (0.39) | GSK3BDYRK1AGRM5SMOMALT1 | |
| SCHEMBL17778224 | 0.90 | WNT3A (0.41) | GSK3BNTRK1WNT3A | |
| SCHEMBL19689674 | 0.90 | WNT3A (0.41) | GSK3BNTRK1WNT3A | |
| SCHEMBL17618510 | 0.87 | PIK3CA (0.41) | GSK3BDYRK1AABL1GRM5NTRK1 | |
| SCHEMBL17768133 | 0.86 | HTR2A (0.42) | — | |
| SCHEMBL17778459 | 0.86 | GSK3B (0.38) | GSK3BDYRK1AGRM5NTRK1VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |